The unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier. Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis. PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Ac4GalNAz 是一種屬于 alkyl chain 類(lèi)的 PROTAC linker，可用于 PROTAC 分子的合成。
靶點(diǎn)科技現(xiàn)貨N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) (CCT-1086)
精選文獻(xiàn)Selected References
1.Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301.
2.Ranzinger, R., et al. (2020). Mass Spectrometric Method for the Unambiguous Profiling of Cellular Dynamic Glycosylation. ACS Chem. Biol., 15, 10, 2692-2701.
3.Suttapitugsakul, S., et al. (2019). Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type. Anal. Chem., 91(10), 6934–42.
| 生物活性 | Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | |||
|---|---|---|---|---|
| IC50 & Target |
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| 體外研究 (In Vitro) | PROTAC 包含兩個(gè)不同的配體，通過(guò)一個(gè)接頭連接；一個(gè)是 E3 泛素連接酶的配體，另一個(gè)是靶蛋白的配體。PROTAC 利用細(xì)胞內(nèi)泛素-蛋白酶體系統(tǒng)選擇性降解靶蛋白[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. | |||
| 分子量 | 430.37 | |||
| Formula | C16H22N4O10 | |||
| CAS 號(hào) | 653600-56-7 | |||
| 性狀 | 固體 | |||
| 顏色 | White to off-white | |||
| 運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | |||
| 儲(chǔ)存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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